Astaxanthin (3,3'-dihydroxy-beta,beta-carotene-4,4'-dione) bụ carotenoid, nkewapụtara dị ka lutein, nke a chọtara n'ụdị dị iche iche nke microorganisms na anụmanụ mmiri, nke Kuhn na Sorensen kewapụrụ na lobsters. Ọ bụ pigmenti na-agbaze abụba nke na-egosi oroma na-acha ọbara ọbara miri emi na agba na enweghị vitamin A pro-ọrụ n'ime ahụ mmadụ.
Isi mmalite nke astaxanthin gụnyere algae, yist, salmon, trout, krill na crayfish. Astaxanthin azụmaahịa sitere na yist Fife, algae uhie na njikọ kemịkalụ. Otu n'ime ebe kacha mma astaxanthin sitere n'okike bụ chlorella na-acha uhie uhie, nke nwere ọdịnaya astaxanthin dị ihe dịka 3.8% (site na ibu akọrọ), na salmon ọhịa bụkwa ezigbo isi mmalite nke astaxanthin. Mmepụta sịntetik ka bụ isi ebe astaxanthin na-enweta n'ihi ọnụ ahịa dị ukwuu nke ịkọ Rhodococcus rainieri. Ọrụ ndu nke astaxanthin sitere na synthetically emepụtara bụ naanị 50% nke astaxanthin eke.
Astaxanthin dị dị ka stereoisomers, geometric isomers, ụdị n'efu na esterified, yana stereoisomers (3S,3'S) na (3R,3'R) bụ ndị kasị ukwuu na okike. Rhodococcus rainieri na-emepụta (3S,3'S) -isomer na yist Fife na-emepụta (3R,3'R) -isomer.
Astaxanthin, okpomọkụ nke oge
Astaxanthin bụ star ingredient in ọtọ nri na Japan.FTA si statistics on ọtọ nri nkwupụta na Japan na 2022 chọpụtara na astaxanthin e họọrọ No. 7 n'ime top 10 Efrata na okwu nke ugboro nke ojiji, na bụ tumadi ji na ahụike ubi nke skincare, anya nlekọta, ike ọgwụgwụ, na mma nke cognitive ọrụ.
Na 2022 na 2023 Asia Nutritional Ingredients Awards,Justgood Health's eke astaxanthin ingredient amatara dị ka ihe kacha mma n'ime afọ maka afọ abụọ na-esochi, ihe kacha mma n'ime usoro ọrụ cognitive na 2022, na ihe kachasị mma na egwu egwu ọnụ na 2023. Tụkwasị na nke ahụ, a na-edepụta ihe ahụ na Asia Nutritional Ingredient Awards 2023.
N'ime afọ ndị na-adịbeghị anya, nchọpụta agụmakwụkwọ na astaxanthin amalitekwala ikpo ọkụ. Dị ka data PubMed si kwuo, dị ka 1948, e nwere ọmụmụ banyere astaxanthin, ma nlebara anya dị ala, malite na 2011, academia malitere ilekwasị anya na astaxanthin, nke nwere ihe karịrị 100 akwụkwọ kwa afọ, na ihe karịrị 200 na 2017, karịa 300 na 2040, na karịa 2020.
Isi mmalite nke onyonyo a: PubMed
N'ihe banyere ahịa, dị ka nghọta ahịa ọdịnihu si kwuo, a na-eche na nha ahịa astaxanthin zuru ụwa ọnụ bụ $ 273.2 nde na 2024 ma na-atụ anya iru $ 665.0 nde site na 2034, na CAGR nke 9.3% n'oge amụma (2024-2034).
Ikike antioxidant dị elu
Ọdịdị pụrụ iche nke Astaxanthin na-enye ya ikike antioxidant dị egwu. Astaxanthin nwere njikọ abụọ jikọtara ọnụ, hydroxyl na otu ketone, yana ma lipophilic na hydrophilic. Njikọ okpukpu abụọ jikọtara ọnụ na etiti ogige ahụ na-enye elektrọn ma na-emeghachi omume na radicals n'efu iji mee ka ha ghọọ ngwaahịa kwụsiri ike ma kwụsị mmeghachi omume agbụ n'efu n'ụdị dị iche iche. Ọrụ ndu ya dị elu karịa nke antioxidants ndị ọzọ n'ihi ikike ya iji jikọọ na membranes cell site na ime.
Ọnọdụ nke astaxanthin na antioxidants ndị ọzọ na membranes cell
Astaxanthin na-arụ ọrụ antioxidant dị ịrịba ama ọ bụghị naanị site na nchacha nke radicals n'efu, kamakwa site na ịgbalite sistemu nchekwa nchekwa cellular site na ịhazi ụzọ ihe metụtara erythroid 2 (Nrf2). Astaxanthin na-egbochi nhazi nke ROS ma na-achịkwa okwu nke oxidative stress-responsive enzymes, dị ka heme oxygenase-1 (HO-1), nke bụ ihe nrịbama nke oxidative.
Uru na ngwa astaxanthin zuru oke
1) Mmelite nke ọrụ ọgụgụ isi
Ọtụtụ nchọpụta ekwenyela na astaxanthin nwere ike igbu oge ma ọ bụ melite adịghị ike nke metụtara ịka nká ma ọ bụ na-ebelata pathophysiology nke ọrịa neurodegenerative dị iche iche. Astaxanthin nwere ike ịgafe ihe mgbochi ụbụrụ nke ọbara, na ọmụmụ egosiwo na astaxanthin nri na-eri nri na-agbakọta na hippocampus na cerebral cortex nke ụbụrụ oke mgbe otu na-eri nri ugboro ugboro, nke nwere ike imetụta mmezi na imeziwanye ọrụ ọgụgụ isi. Astaxanthin na-akwalite mmụba mkpụrụ ndụ akwara ma na-abawanye okwu mkpụrụ ndụ nke glial fibrillary acidic protein (GFAP), protein microtubule 2 (MAP-2), ihe na-akpata ụbụrụ neurotrophic (BDNF), na protein metụtara uto 43 (GAP-43), protein ndị na-etinye aka na mgbake ụbụrụ.
Justgood Health Astaxanthin Capsules, yana Cytisine na Astaxanthin sitere na Red Algae Rainforest, na-emekọrịta ọnụ iji melite ọrụ ọgụgụ isi nke ụbụrụ.
2) Nchekwa anya
Astaxanthin nwere ọrụ antioxidant nke na-ewepụ ikuku oxygen free radical molecules ma na-enye nchebe maka anya. Astaxanthin na-arụ ọrụ synergistically na ndị ọzọ carotenoids na-akwado ahụ ike anya, karịsịa lutein na zeaxanthin. Tụkwasị na nke ahụ, astaxanthin na-abawanye ọnụ ọgụgụ ọbara na-eruba na anya, na-ekwe ka ọbara na-emegharị retina na anụ ahụ anya. Nnyocha e mere egosiwo na astaxanthin, yana ndị ọzọ carotenoids, na-echebe anya site na mmebi n'ofe ụdị dị iche iche nke anyanwụ. Na mgbakwunye, astaxanthin na-enyere aka belata ahụ erughị ala anya na ike ọgwụgwụ anya.
Justgood Health Blue Light Nchekwa Softgels, Isi ihe: lutein, zeaxanthin, astaxanthin.
3) Nlekọta akpụkpọ anụ
Nchegbu oxidative bụ ihe dị mkpa na-akpalite ịka nká akpụkpọ mmadụ na mmebi dermal. Usoro nke ma intrinsic (oge) na extrinsic (ìhè) ịka nká bụ mmepụta nke ROS, n'ime ime site na oxidative metabolism, na extrinsically site ikpughe na anyanwụ ultraviolet (UV) ụzarị. Ihe omume oxidative na ịka nká akpụkpọ gụnyere mmebi DNA, nzaghachi mkpali, mbelata nke antioxidants, na mmepụta nke matrix metalloproteinases (MMPs) nke na-eweda collagen na elastin na dermis.
Astaxanthin nwere ike igbochi mmebi oxidative radical free na ntinye nke MMP-1 na akpụkpọ ahụ mgbe mkpughe UV gasịrị. Nnyocha egosiwo na astaxanthin sitere na Erythrocystis rainbowensis nwere ike ịbawanye ọdịnaya collagen site na igbochi okwu nke MMP-1 na MMP-3 na fibroblasts dermal mmadụ. Na mgbakwunye, astaxanthin belatara mmebi DNA nke UV kpatara yana nrụzi DNA na sel ndị ekpughere na radieshon UV.
Justgood Health na-eme ugbu a ọtụtụ ọmụmụ ihe, gụnyere oke na-enweghị ntutu isi na ule mmadụ, ihe niile egosila na astaxanthin na-ebelata mmebi UV na akpụkpọ ahụ dị omimi, nke na-eme ka ọdịdị nke ihe ịrịba ama nke ịka nká akpụkpọ anụ, dị ka nkụ, akpụkpọ anụ na wrinkles.
4) nri egwuregwu
Astaxanthin nwere ike mee ka nrụzi mgbatị ahụ gasịrị. Mgbe ndị mmadụ na-emega ahụ ma ọ bụ na-emega ahụ, ahụ na-emepụta nnukwu ROS, nke, ọ bụrụ na ewepụghị ya n'oge, nwere ike imebi ahụ ike ma na-emetụta mgbake anụ ahụ, ebe ọrụ antioxidant siri ike nke astaxanthin nwere ike wepụ ROS n'oge ma mezie uru ahụ mebiri emebi ngwa ngwa.
Justgood Health na-ewebata ihe ọhụrụ Astaxanthin Complex, ngwakọta nke magnesium glycerophosphate, vitamin B6 (pyridoxine), na astaxanthin nke na-ebelata ahụ mgbu na ike ọgwụgwụ mgbe mgbatị ahụ gasịrị. Usoro a gbadoro ụkwụ na gburugburu Justgood Health's Whole Algae Complex, nke na-ebuga astaxanthin eke na ọ bụghị naanị na-echebe akwara site na mmebi oxidative, kamakwa na-eme ka arụ ọrụ akwara dịkwuo mma ma na-eme ka arụmọrụ egwuregwu dịkwuo mma.
5) Ahụike obi
Oxidative nchekasị na mbufụt na-akọwa pathophysiology nke atherosclerotic ọrịa obi. Ọrụ antioxidant kachasị mma nke astaxanthin nwere ike igbochi ma melite atherosclerosis.
Justgood Health Triple Strength Natural Astaxanthin Softgels na-enyere aka ịnọgide na-enwe ahụike obi site na iji astaxanthin eke sitere na algae egwurugwu na-acha uhie uhie, ihe bụ isi nke gụnyere astaxanthin, mmanụ aki oyibo na-amaghị nwoke na tocopherols eke.
6) Usoro mgbochi ọrịa
Ndị na-ahụ maka usoro ahụ ji alụso ọrịa ọgụ na-enwe mmetụta nke ukwuu maka mmebi radical free. Astaxanthin na-echebe ihe nchebe nke usoro ahụ ji alụso ọrịa ọgụ site na igbochi mmebi radical n'efu. Otu nnyocha chọpụtara na astaxanthin na mkpụrụ ndụ mmadụ iji mepụta immunoglobulins, n'ime ahụ mmadụ astaxanthin supplementation maka izu 8, ọkwa astaxanthin dị n'ọbara mụbara, mkpụrụ ndụ T na B na-abawanye, mmebi DNA na-ebelata, protein C-reactive na-ebelata nke ukwuu.
Astaxanthin softgels, raw astaxanthin, na-eji ìhè anyanwụ eke, lava-nzacha mmiri na ike anyanwụ na-emepụta astaxanthin dị ọcha ma dị mma, nke nwere ike inye aka kwalite mgbochi, chebe ọhụụ na ahụike nkwonkwo.
7) Wepụ ike ọgwụgwụ
Otu izu 4 nke randomized, okpukpu abụọ kpuru ìsì, ebe a na-achịkwa ebebo, nchọpụta crossover ụzọ abụọ chọpụtara na astaxanthin kwalitere mgbake site na njedebe ihe ngosi (VDT) na-akpata ike ọgwụgwụ nke uche, na-ebelata ọkwa plasma phosphatidylcholine hydroperoxide (PCOOH) dị elu n'oge ma nke uche na nke anụ ahụ. Ihe kpatara ya nwere ike ịbụ ọrụ antioxidant na usoro mgbochi mkpali nke astaxanthin.
8) Nchekwa imeju
Astaxanthin nwere mmetụta mgbochi na ọgwụgwọ na nsogbu ahụike dịka imeju fibrosis, imeju ischemia-reperfusion mmerụ, na NAFLD. Astaxanthin nwere ike ịhazi ụzọ dị iche iche nke akara ngosi, dị ka ibelata ọrụ JNK na ERK-1 iji meziwanye nguzogide insulin imeju, na-egbochi okwu PPAR-γ iji belata njikọ abụba imeju, na okwu TGF-β1 / Smad3 na-achịkwa iji gbochie HSC na-arụ ọrụ na fibrosis imeju.
Ọnọdụ iwu na obodo ọ bụla
Na China,astaxanthin site na isi iyi nke egwurugwu uhie algae nwere ike ji mee ihe dị ka a ọhụrụ nri mgwa n'ozuzu nri (ma e wezụga nri nwa), na mgbakwunye, na United States, Canada na Japan na-ekwe ka astaxanthin na-eji nri .
Oge nzipu: Dec-05-2024