Astaxanthin (3,3'-dihydroxy-beta,beta-carotene-4,4'-dione) bụ carotenoid, nke a na-akpọ lutein, nke a na-ahụ n'ọtụtụ nje na anụmanụ mmiri, Kuhn na Sorensen kewapụrụ na mbụ site na lobster. Ọ bụ agba na-agbaze abụba nke na-adị ka oroma ruo ọbara ọbara miri emi ma enweghị vitamin A pro-activity n'ahụ mmadụ.
Isi mmalite eke nke astaxanthin gụnyere algae, yist, salmon, trout, krill na crayfish. Astaxanthin azụmaahịa sitere na yist Fife, algae uhie na mmepụta kemịkalụ. Otu n'ime isi mmalite kacha mma nke astaxanthin eke bụ chlorella uhie mmiri ozuzo, nke nwere ihe dị ka 3.8% (site na oke akọrọ), salmon ọhịa bụkwa ezigbo isi mmalite nke astaxanthin. Mmepụta sịntetik ka bụ isi iyi nke astaxanthin n'ihi oke ọnụ ahịa nke ịkọ Rhodococcus rainieri buru ibu. Ọrụ bayoloji nke astaxanthin e ji aka mepụta bụ naanị 50% nke astaxanthin eke.
Astaxanthin dị ka stereoisomers, isomers geometric, ụdị free na esterified, yana stereoisomers (3S,3'S) na (3R,3'R) bụ ndị kachasị baa ụba n'okike. Rhodococcus rainieri na-emepụta isomer (3S,3'S) ebe yist Fife na-emepụta isomer (3R,3'R) (3R,3'R).
Astaxanthin, okpomọkụ nke oge a
Astaxanthin bụ ihe kacha mkpa na nri bara uru na Japan. Ọnụọgụgụ FTA na nkwupụta nri bara uru na Japan na 2022 chọpụtara na astaxanthin nọ n'ọkwa nke 7 n'ime ihe iri kachasị mma n'ihe gbasara ugboro ole e ji ya eme ihe, a na-ejikwa ya eme ihe karịsịa n'ihe gbasara nlekọta akpụkpọ ahụ, nlekọta anya, enyemaka ike ọgwụgwụ, na imeziwanye ọrụ ọgụgụ isi.
Na onyinye nri nri Eshia nke afọ 2022 na 2023,Ahụike Justgood A matara ihe e ji eme astaxanthin eke dị ka ihe kacha mma n'afọ a ruo afọ abụọ n'usoro, ihe kacha mma n'usoro ọrụ nghọta na 2022, na ihe kacha mma n'usoro mma ọnụ na 2023. Na mgbakwunye, e tinyere ihe e ji mee ya na ndepụta Asian Nutritional Ingredients Awards - Healthy Aging na 2024.
N'afọ ndị na-adịbeghị anya, nnyocha agụmakwụkwọ gbasara astaxanthin amalitekwala ịka njọ. Dịka data PubMed si kwuo, na mbido afọ 1948, e nwere ọmụmụ ihe gbasara astaxanthin, mana nlebara anya adịghị ala, malite na 2011, agụmakwụkwọ malitere ilekwasị anya na astaxanthin, na-enwe ihe karịrị mbipụta 100 kwa afọ, na ihe karịrị 200 na 2017, ihe karịrị 300 na 2020, na ihe karịrị 400 na 2021.
Isi mmalite nke onyonyo: PubMed
Dịka echiche ahịa Future si dị, a na-eme atụmatụ na nha ahịa astaxanthin zuru ụwa ọnụ ga-abụ $273.2 nde na 2024 ma a na-atụ anya na ọ ga-eru $665.0 nde ka ọ na-erule 2034, na CAGR nke 9.3% n'oge amụma (2024-2034).
Ike antioxidant dị elu
Ọdịdị pụrụ iche nke Astaxanthin na-enye ya ikike antioxidant dị egwu. Astaxanthin nwere njikọ abụọ, otu hydroxyl na ketone, ma ọ bụ lipophilic na hydrophilic. Njikọ abụọ ejikọtara ọnụ n'etiti ihe mejupụtara ahụ na-enye elektrọn ma na-emeghachi omume na free radicals iji gbanwee ha ka ha bụrụ ngwaahịa kwụsiri ike ma kwụsị mmeghachi omume free radicals n'ime ihe dị ndụ dị iche iche. Ọrụ ndu ya dị elu karịa nke antioxidants ndị ọzọ n'ihi ikike ya ijikọ na akpụkpọ ahụ sel site n'ime gaa n'èzí.
Ọnọdụ nke astaxanthin na antioxidants ndị ọzọ dị na membranes cell
Astaxanthin na-arụ ọrụ dị mkpa nke antioxidant ọ bụghị naanị site na iwepụ ihe ndị na-emebi emebi n'efu, kamakwa site na ịgbalite sistemụ nchekwa antioxidant cellular site na ịchịkwa ụzọ ihe metụtara ihe abụọ nke nuclear factor erythroid (Nrf2). Astaxanthin na-egbochi mmepụta nke ROS ma na-achịkwa ngosipụta nke enzymes na-aza nrụgide oxidative, dị ka heme oxygenase-1 (HO-1), nke bụ ihe nrịbama nke nrụgide oxidative. A na-achịkwa HO-1 site na ọtụtụ ihe ntụgharị uche na-emetụta nrụgide, gụnyere Nrf2, nke na-ejikọ na ihe ndị na-aza antioxidant na mpaghara nkwalite nke enzymes metabolism detoxification.
Uru na ojiji nke astaxanthin zuru oke
1) Mmezi nke ọrụ nghọta
Ọtụtụ nnyocha egosila na astaxanthin nwere ike igbu oge ma ọ bụ melite ụkọ ọgụgụ isi nke metụtara ịka nká nkịtị ma ọ bụ belata ọrịa nke ọrịa neurodegenerative dị iche iche. Astaxanthin nwere ike ịgafe ihe mgbochi ọbara-ụbụrụ, ọmụmụ ihe egosikwala na astaxanthin nri na-agbakọta na hippocampus na cerebral cortex nke ụbụrụ oke mgbe a na-aṅụ ya otu ugboro na ugboro ugboro, nke nwere ike imetụta mmezi na mmezi nke ọrụ ọgụgụ isi. Astaxanthin na-akwalite mmeghari mkpụrụ ndụ akwara ma na-eme ka mpụta mkpụrụ ndụ ihe nketa nke glial fibrillary acidic protein (GFAP), microtubule-associated protein 2 (MAP-2), ụbụrụ-enweta neurotrophic factor (BDNF), na protein 43 (GAP-43), protein ndị metụtara uto, dị na mgbake ụbụrụ.
Justgood Health Astaxanthin Capsules, ya na Cytisine na Astaxanthin sitere na Red Algae Rainforest, na-arụkọ ọrụ iji melite ọrụ ọgụgụ isi nke ụbụrụ.
2) Nchedo Anya
Astaxanthin nwere ọrụ antioxidant nke na-eme ka mkpụrụ ndụ ihe nketa oxygen ghara ịdị irè ma na-echebe anya. Astaxanthin na-arụkọ ọrụ ọnụ na carotenoids ndị ọzọ na-akwado ahụike anya, ọkachasị lutein na zeaxanthin. Na mgbakwunye, astaxanthin na-eme ka ọbara na-eruba n'anya dịkwuo elu, na-enye ọbara ohere ịmegharị retina na anụ ahụ anya. Ọmụmụ ihe egosila na astaxanthin, yana carotenoids ndị ọzọ, na-echebe anya pụọ na mmebi n'ofe spectrum anyanwụ. Na mgbakwunye, astaxanthin na-enyere aka belata ahụ erughị ala anya na ike ọgwụgwụ anya.
Justgood Health Blue Light Protection Softgels, Ihe ndị dị mkpa: lutein, zeaxanthin, astaxanthin.
3) Nlekọta Akpụkpọ Ahụ
Nrụgide Oxidative bụ ihe dị mkpa na-akpata ịka nká na mmebi akpụkpọ ahụ mmadụ. Usoro nke ịka nká n'ime ahụ (oge) na nke mpụga (ìhè) bụ mmepụta nke ROS, n'ime ya site na metabolism oxidative, na n'èzí site na ikpughe na ụzarị ultraviolet (UV) anyanwụ. Ihe omume oxidative na ịka nká akpụkpọ ahụ gụnyere mmebi DNA, nzaghachi mkpali, mbelata nke antioxidants, na mmepụta nke matrix metalloproteinases (MMPs) nke na-emebi collagen na elastin na dermis.
Astaxanthin nwere ike igbochi mmebi oxidative nke sitere na radical na-akpata na MMP-1 n'ime akpụkpọ ahụ mgbe ekpughere UV. Ọmụmụ ihe egosila na astaxanthin sitere na Erythrocystis rainbowensis nwere ike ịbawanye ọdịnaya collagen site na igbochi ngosipụta nke MMP-1 na MMP-3 na fibroblasts akpụkpọ ahụ mmadụ. Na mgbakwunye, astaxanthin belatara mmebi DNA nke UV kpatara ma mụbaa mmezi DNA na mkpụrụ ndụ ndị e kpughere na radieshon UV.
Justgood Health na-eme ọtụtụ nnyocha ugbu a, gụnyere oke na-enweghị ntutu isi na nnwale mmadụ, ihe niile egosila na astaxanthin na-ebelata mmebi UV na akwa miri emi nke akpụkpọ ahụ, nke na-eme ka a mata ihe ịrịba ama nke ịka nká akpụkpọ ahụ, dị ka nkụ, akpụkpọ ahụ na-ada ada na wrinkles.
4) Nri egwuregwu
Astaxanthin nwere ike ime ka mmezi ahụ dị ngwa mgbe emechara mmega ahụ. Mgbe mmadụ na-eme mmega ahụ ma ọ bụ na-eme mmega ahụ, ahụ na-emepụta nnukwu ROS, nke, ọ bụrụ na ewepụghị ya n'oge, nwere ike imebi akwara ma metụta mgbake anụ ahụ, ebe ọrụ antioxidant siri ike nke astaxanthin nwere ike iwepụ ROS n'oge ma rụzie akwara ndị mebiri emebi ngwa ngwa.
Justgood Health webatara Astaxanthin Complex ọhụrụ ya, ngwakọta nke magnesium glycerophosphate, vitamin B6 (pyridoxine), na astaxanthin nke na-ebelata ihe mgbu na ike ọgwụgwụ mgbe emechara mmega ahụ. Usoro a lekwasịrị anya na Justgood Health's Whole Algae Complex, nke na-enye astaxanthin eke nke na-echebeghị naanị akwara site na mmebi oxidative, kamakwa ọ na-eme ka akwara rụọ ọrụ nke ọma ma na-eme ka arụmọrụ egwuregwu ka mma.
5) Ahụike Obi
Nrụgide na mbufụt na-egosi ọrịa obi na arịa ọbara nke atherosclerotic. Ọrụ antioxidant dị mma nke astaxanthin nwere ike igbochi ma melite atherosclerosis.
Justgood Health Triple Strength Natural Astaxanthin Softgels na-enyere aka ịnọgide na-enwe ahụike obi site na iji astaxanthin eke sitere na algae uhie na-acha uhie uhie, ihe ndị bụ isi mejupụtara ya gụnyere astaxanthin, mmanụ aki oyibo organic na tocopherols eke.
6) Iwu Mgbochi Ahụ́
Mkpụrụ ndụ ndị na-alụso ọrịa ọgụ na-enwe mmetụta dị ukwuu na mmebi radical efu. Astaxanthin na-echebe nchebe nke sistemu ahụ ji alụso ọrịa ọgụ site na igbochi mmebi radical efu. Nnyocha chọpụtara na astaxanthin dị na mkpụrụ ndụ mmadụ iji mepụta immunoglobulin, na mgbakwunye astaxanthin n'ime ahụ mmadụ ruo izu asatọ, ọkwa astaxanthin dị n'ọbara mụbara, mkpụrụ ndụ T na mkpụrụ ndụ B mụbara, mmebi DNA belatara, protein C-reactive belatara nke ukwuu.
Astaxanthin softgels, astaxanthin raw, na-eji anwụ eke, mmiri e ji lava ehichapụ na ike anyanwụ emepụta astaxanthin dị ọcha ma dị mma, nke nwere ike inye aka melite ọgụ, chebe anya na ahụike nkwonkwo.
7) Belata Ike ọgwụgwụ
Nnyocha e mere n'izu anọ nke e ji usoro nhazi, nke a na-achịkwa site na placebo, gosiri na astaxanthin na-akwalite mgbake site na ike ọgwụgwụ uche nke ihe ngosi anya (VDT) kpatara, na-ebelata ọkwa plasma phosphatidylcholine hydroperoxide (PCOOH) dị elu n'oge mmega ahụ uche na anụ ahụ. Ihe kpatara ya nwere ike ịbụ ọrụ antioxidant na usoro mgbochi mkpali nke astaxanthin.
8) Nchedo imeju
Astaxanthin nwere mmetụta mgbochi na ọgwụgwọ na nsogbu ahụike dịka fibrosis imeju, mmerụ ahụ imeju ischemia-reperfusion, na NAFLD. Astaxanthin nwere ike ịchịkwa ọtụtụ ụzọ mgbaàmà, dịka ibelata ọrụ JNK na ERK-1 iji melite iguzogide insulin imeju, igbochi ngosipụta PPAR-γ iji belata njikọta abụba imeju, na ibelata ngosipụta TGF-β1/Smad3 iji gbochie mmegharị HSC na fibrosis imeju.
Ọnọdụ iwu dị na mba ọ bụla
Na Chaịna,astaxanthin Site na isi iyi nke algae uhie nwere ike iji dị ka ihe ọhụrụ e ji eme nri n'ozuzu (ma e wezụga nri ụmụaka), na mgbakwunye, United States, Canada na Japan na-enyekwa ohere iji astaxanthin mee ihe na nri.
Oge ozi: Disemba-05-2024